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Every action in Align Pro (align, distribute, and distribute spacing) is measured against a target you choose first. This is the Align to control at the top of the panel, shown as either a row of icon buttons or a dropdown menu depending on your panel preferences.
Some Align to targets disable specific buttons or modifiers that wouldn’t make sense together. For example, Outside disables centering, since “outside” is only meaningful at an edge. See Modifiers.